Alzheimer's disease and serotonin: a review - PubMed

Alzheimer's disease and serotonin: a review Abstract Data from post-mortem brain, cerebrospinal fluid and serotonin (5-HT) synapse studies indicate se...
Alzheimer's disease and serotonin: a review Abstract Data from post-mortem brain, cerebrospinal fluid and serotonin (5-HT) synapse studies indicate serious impairment of the serotoninergic system in patients with Alzheimer's disease.Also, while many of these compounds will likely find application as adjuvant therapy in the symptomatic treatment of Alzheimer's disease, there are currently only a few drug entities with activity against serotonin receptors that may offer the potential to alter the progression of the disease. Publication types Review MeSH termsMemantine is used for moderate or severe Alzheimer's disease. It's suitable for those who cannot take or are unable to tolerate AChE inhibitors. It's also suitable for people with severe Alzheimer’s disease who are already taking an AChE inhibitor. Side effects can include headaches, dizziness and constipation but these are usually only temporary.Past studies have noted that people with Alzheimer’s disease have less serotonin in their brains than other adults. The chemical monitors and regulates appetite, mood, sexual function, sleep and more in the body. Recent studies now suggest that low serotonin levels may be more than a side effect of Alzheimer’s – it may actually drive the disease.OBJECTIVE: The aim was to quantitatively review published studies to examine the efficacy of selective serotonin reuptake inhibitor (SSRI)/serotonin-noradrenaline (norepinephrine) reuptake inhibitor (SNRI) therapy for alleviation of comorbid, diagnosed depression as well as cognitive decline in AD.New research carried out by scientists from the Johns Hopkins University School of Medicine in Baltimore, MD, confirms that the neurotransmitter serotonin does play a key role in Alzheimer’s.
Because of the extensive serotonergic denervation obtained in the AD brain, as well as an important role of serotonin (5-hydroxytryptamine; 5-HT) in both cognition and behavioural control, this neurotransmitter system has become a focus of a concerted research effort to identify new treatments for AD.Taken together, it might be suggested that, through its enhancing catecholaminergic and serotonergic activities, AP-2β may exert a protective role in AD. .
The regulatory role of AP-2β in.
Serotonin can be a missing link to treating Alzheimer’s Disease and be used as a therapeutic target in the future. With that being said, Serotonin is not a panacea for mental health. There are several other neurotransmitters that are equally important. To understand if Serotonin can be beneficial for your mental health, talk to your physician.Current Alzheimer's treatments temporarily improve symptoms of memory loss and problems with thinking and reasoning. These Alzheimer's treatments boost performance of chemicals in the brain that carry information from one brain cell to another. However, these treatments don't stop the underlying decline and death of brain cells.

14 August 2021, 10:30 | Views: 175

Add new comment

For adding a comment, please log in
or create account

0 comments